Carol Wagner of Northern Kentucky lost her son to a heroin overdose in May of 2005, and organized the march.
This year she had a billboard reading "Drugs killed my boy." placed in Over The Rhine and other drug hot spots.
The group marched through the streets of downtown not far from areas where drug dealers are known to do their business.
Charlotte Wethington said, "My son Casey died of a heroin overdose. Heroin he purchased on Republic street here in Cincinnati."
Casey was 23 years old. His mom took to the streets with a sign asking for treatment to become a top priority.